Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
9
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
9
Eicosapentaenoic acid alleviates back pain
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.
In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
9
We conducted a thorough investigation into how eicosapentaenoic acid (EPA) could relieve chronic low-back and knee pain in adults. The study was carefully structured as a randomized, double-blind, placebo-controlled trial, which helps ensure that the findings are reliable and unbiased.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Our participants, totaling 120 adults who had been suffering from pain in their low back and knees for at least three months, were divided into two groups. One group received a daily dose of 594 mg of l-serine combined with 149 mg of EPA, while the other group received a placebo. Over the course of eight weeks, we tracked their progress using various pain measurement tools.
The results were promising, showing that both l-serine and EPA together led to meaningful reductions in pain scores. This suggests that including EPA in treatment plans could be beneficial for those suffering from persistent low-back pain.
Our trial highlighted the importance of this combination in pain relief, particularly for chronic conditions. The findings from this study hold potential for guiding future treatments aimed at enhancing the quality of life for many suffering from chronic pain.
Most Useful Reviews
9
Reduced back pain
7 people found this helpful
I ordered omega after reading positive reviews. I didn’t expect such a result. My back pain eased, and the discomfort in my lower abdomen disappeared. After taking omega, there was no more tone on the second ultrasound. Omega also supports the development of the baby’s brain and promotes skin elasticity. I intend to continue taking omega throughout my pregnancy and beyond.
6
Improved condition
1 people found this helpful
I haven't experienced a bad smell, which is good. Although I did have some headaches, after eating two cups of something, it quickly made me feel better. Now, I’m just consuming one more cup and feeling good.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
- All Researches
9.5
We observed a rare condition known as pregnancy-associated osteoporosis, which affected a 38-year-old woman after she gave birth. Just a month postpartum, she experienced sudden back pain due to four vertebral fractures, and her bone density was notably low, especially in the spine.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
9.5
We explored the impact of various treatments, including vitamin D3, on severe back pain caused by pregnancy-related osteoporosis (PLO). In a significant case study, a 23-year-old woman experiencing debilitating back pain was treated after her first childbirth. By monitoring her bone mineral density, we noted low T- and Z-scores in her lumbar spine.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
9
We explored the effectiveness of denosumab on alleviating back pain and enhancing quality of life in post-menopausal women suffering from vertebral fractures. This study, involving 140 women aged around 70, assessed participants who received denosumab alongside calcium and vitamin D3 for a year.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
9
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
9
We investigated the impact of adding 4000 IU of vitamin D3 on managing musculoskeletal pain, which includes back pain. In our study, we designed a randomized, double-blind, placebo-controlled trial involving 80 patients over three months. Each participant received either the vitamin D supplement or a placebo while their pain levels were monitored.
Our findings revealed that the group taking vitamin D experienced greater improvements in their pain levels, as measured by the Visual Analogue Scale (VAS). Notably, they reported a significant decline in pain compared to those receiving the placebo. Additionally, the need for rescue analgesics was markedly reduced among patients receiving vitamin D.
We also observed interesting changes in inflammatory markers. Specifically, levels of tumor necrosis factor alpha (TNFα) and prostaglandin E2 (PGE2) dropped significantly in the vitamin D group, indicating less inflammation compared to the placebo group, which actually saw increases in these markers.
In conclusion, incorporating a high dose of vitamin D may provide relief for those suffering from musculoskeletal pain, potentially through its effects on inflammation and pain perception.
Our findings revealed that the group taking vitamin D experienced greater improvements in their pain levels, as measured by the Visual Analogue Scale (VAS). Notably, they reported a significant decline in pain compared to those receiving the placebo. Additionally, the need for rescue analgesics was markedly reduced among patients receiving vitamin D.
We also observed interesting changes in inflammatory markers. Specifically, levels of tumor necrosis factor alpha (TNFα) and prostaglandin E2 (PGE2) dropped significantly in the vitamin D group, indicating less inflammation compared to the placebo group, which actually saw increases in these markers.
In conclusion, incorporating a high dose of vitamin D may provide relief for those suffering from musculoskeletal pain, potentially through its effects on inflammation and pain perception.
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced back pain
7 people found this helpful
I ordered omega after reading positive reviews. I didn’t expect such a result. My back pain eased, and the discomfort in my lower abdomen disappeared. After taking omega, there was no more tone on the second ultrasound. Omega also supports the development of the baby’s brain and promotes skin elasticity. I intend to continue taking omega throughout my pregnancy and beyond.
6
Improved condition
1 people found this helpful
I haven't experienced a bad smell, which is good. Although I did have some headaches, after eating two cups of something, it quickly made me feel better. Now, I’m just consuming one more cup and feeling good.
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. 10.1097/MD.0000000000032672
- Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. 10.1097/BRS.0000000000004309
- Ma Y, Wu X, Xiao X, Ma Y, Feng L, et al. Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in postmenopausal females with acute osteoporotic vertebral compression fracture: A prospective cohort study. Bone. 2020;131:115154. 10.1016/j.bone.2019.115154
- Pishgahi A, Dolatkhah N, Shakouri SK, Hashemian M, Amiri A, et al. Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study. BMC Res Notes. 2019;12:738. 10.1186/s13104-019-4768-0
- Krasowska K, Skrobot W, Liedtke E, Sawicki P, Flis DJ, et al. The Preoperative Supplementation With Vitamin D Attenuated Pain Intensity and Reduced the Level of Pro-inflammatory Markers in Patients After Posterior Lumbar Interbody Fusion. Front Pharmacol. 2019;10:527. 10.3389/fphar.2019.00527
- Moretti A, de Sire A, Curci C, Toro G, Gimigliano F, et al. Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures. Curr Med Res Opin. 2019;35:151. 10.1080/03007995.2018.1545636
- Brady SRE, Naderpoor N, de Courten MPJ, Scragg R, Cicuttini F, et al. Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults. J Steroid Biochem Mol Biol. 2019;185:212. 10.1016/j.jsbmb.2018.09.005
- Dzik K, Skrobot W, Flis DJ, Karnia M, Libionka W, et al. Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain. Eur J Appl Physiol. 2018;118:143. 10.1007/s00421-017-3755-1
- Englund M, Persson J, Bergström I. Lower pain and higher muscular strength in immigrant women with vitamin D deficiency following vitamin D treatment. Int J Circumpolar Health. 2017;76:1340547. 10.1080/22423982.2017.1340547
- Gaudio A, Fiore CE. Successful neridronate therapy in pregnancy-associated osteoporosis. Clin Cases Miner Bone Metab. 2016;13:241. 10.11138/ccmbm/2016.13.3.241
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- Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, et al. Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures. J Bone Miner Metab. 2017;35:544. 10.1007/s00774-016-0791-6
- Polat SB, Evranos B, Aydin C, Cuhaci N, Ersoy R, et al. Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature. Gynecol Endocrinol. 2015;31:522. 10.3109/09513590.2015.1014787
- Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus. 2015;24:483. 10.1177/0961203314558676
- Shin MY, Kang YE, Kong SE, Ju SH, Back MK, et al. A case of low bone mineral density with vitamin d deficiency due to prolonged lactation and severe malnutrition. J Bone Metab. 2015;22:39. 10.11005/jbm.2015.22.1.39
- Sanders AE, Weatherspoon ED, Ehrmann BM, Soma PS, Shaikh SR, et al. Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions. J Pain. 2023;24:478. 10.1016/j.jpain.2022.10.008
- Lin Z, Ni L, Teng C, Zhang Z, Wu L, et al. Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis. Front Cell Dev Biol. 2021;9:745621. 10.3389/fcell.2021.745621
- Sasahara I, Yamamoto A, Takeshita M, Suga Y, Suzuki K, et al. l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2020;150:2278. 10.1093/jn/nxaa156
- NaPier Z, Kanim LEA, Arabi Y, Salehi K, Sears B, et al. Omega-3 Fatty Acid Supplementation Reduces Intervertebral Disc Degeneration. Med Sci Monit. 2019;25:9531. 10.12659/MSM.918649
- Kawabata F, Tsuji T. Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans. Biomed Res. 2011;32:387.
- Moghadamnia AA, Mirhosseini N, Abadi MH, Omranirad A, Omidvar S. Effect of Clupeonella grimmi (anchovy/kilka) fish oil on dysmenorrhoea. East Mediterr Health J. 2010;16:408.
- Maroon JC, Bost JW. Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain. Surg Neurol. 2006;65:326.
- Dai Y, Chen Y, Gu R, Zhang C, Jiang R. Causal association of polyunsaturated fatty acids with chronic pain: a two-sample Mendelian randomization study. Front Nutr. 2023;10:1265928. 10.3389/fnut.2023.1265928
